1. question (e.g. on a test); problem
次の問題だよ。Here's the next question.
2. problem (e.g. societal, political); question; issue; subject (e.g. of research); case; matter
ここが問題の中心です。This is the center of the problem.
3. question (i.e. doubt)
4. public discussion; controversy
5. trouble; problem; inconvenience; difficulty
だから問題はないだろう。So there should be no problem.