not insignificant; not to be sneezed at
someone (something) not to be trifled with
a born fool is never cured; there is no cure for stupidity; (lit.) there is no medicine for fools
a born fool is never cured; there is no cure for stupidity; (lit.) there is no medicine for fools
a born fool is never cured; there is no cure for stupidity; (lit.) there is no medicine for fools
a born fool is never cured; there is no cure for stupidity; (lit.) there is no medicine for fools