1.  to blame;  to reproach;  to censure;  to rebuke;  to reprove;  to find fault;  to take to task;  to criticize;  to criticise
2.  to question (a suspect);  to challenge
3.  to aggravate (an injury);  to be aggravated;  to get inflamed
Verb (1-dan, intransitive)
4.  to prick (one's conscience)